The historic at Cedar Crest and Hamilton boulevards in South Whitehall has closed.
A message on the restaurant's answering machine says, "We're sorry. The King George Inn is now closed for business. Thank you for your patronage the past 42 years."
No other additional information was immediately available.
The inn was built in 1756, and even before the Revolutionary War, it was serving weary travelers.
It has been designated a National Historic Site by the National Park Service, U.S. Department of the Interior.
The land surrounding the inn was recently purchased by , where a Burger King and video store once operated. The real estate company that handled the transaction said the land will be banked for now but that a hotel is likely to be constructed on the site.
The stretch of Hamilton Boulevard where the restaurant sits has seen much recent activity. In addition to the Hotel Hamilton purchase, a new three-story medical office building is rising on Hamilton Boulevard, next door to Also in the block, another will be constructed at the site of a former miniature golf business.
Also, jeweler closed after decades at the corner of Hamilton and Cedar Crest boulevards. No plans have been announced for that site.